Endocrine Abstracts

Impaired glucagon suppression is an overlooked contributor to the transition of prediabetes to type 2 diabetes. We used Graded Glucose Infusion (GGI) to examine the relationship of ISR and Glucagon Secretion Rate (GSR) with rising glucose. We studied 39 non-diabetic, weight-stable individuals (53±2 yrs, 30±1 Kg/M2) categorized by fasting and glucose tolerance status following a 75g OGTT at the time of screening. After an overnight fast, at 07:00 a variable ins...